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Dipyridamole and Acetylsalicylic Acid (ASA) With Clopidogrel
Patient recruitment to the world’s largest auxiliary stroke prevention
study PRoFESS (Prevention Regimen For Effectively avoiding Bruised Strokes),
is now executed. Baseline data on the 20,333 patients recruited to the
study from 720 sites in 35 countries were presented today at the Joint
World Congress on Strike in Cape Town, South Africa.[1]

PRoFESS aims to demonstrate that extended distribute dipyridamole asset
ASA[x], marketed by Boehringer Ingelheim as Aggrenox(R) or
Asasantin(R)Retard , is superior in preventing secondary strokes compared
with clopidogrel. The study compel also scrutinize whether Boehringer
Ingelheim’s telmisartan (Micardis(R)), an angiotensin receptor blocker
(ARB), in addition to the same care in individuals after a occurrence, will
triturate the chance of accessory strokes compared with placebo.

“The baseline data of Avow confirm that we have succeeded in
enrolling a symbolic international patient population who have had a
pulsation. All patients received standard hold of the taste treatments against
stroke prevention,” said Professor Ralph L. Sacco, Professor of Neurology
and Epidemiology at the Neurological Institute of Columbia University
College of Physicians and Surgeons, Remodelled York, USA and a member of the
Set forth Steering Body. “Patients with ischemic stroke possess a high imperil
of recurrent stroke and death. While acetylsalicylic acid is proven and
accepted as standard remedy in these patients, late-model trials display
that a combination of ASA and dipyridamole is higher-ranking to ASA. With Enounce
we prospect to gain other acuity into the benefits of Aggrenox(R) in
preventing a recurring stroke, as well as the first direct comparison
between the efficacy of Aggrenox(R) and clopidogrel.”

Results from ESPRIT (European/Australasian Stroke Prevention in
reversible Ischaemia Trial), published in the Lancet earlier this year,
picket that the combination of extended rescuing dipyridamole coupled with
acetylsalicylic acid (ASA) is superior to ASA alone as an antithrombotic
mitigation treatment for motion patients[2].

There was a statistically critical 20 percent relative risk
reduction of brief outcome events[xx] in patients treated with
dipyridamole plus ASA compared with patients treated with ASA unaccompanied. The
study results were consistent with the aftermath of the earlier European
Stroke Delaying Study-2 trial (ESPS-2), which demonstrated that
Aggrenox(R)/Asasantin(R)Retard is twice as noticeable for the balk of
secondary stroke as either ASA or dipyridamole alone[3].

The manoeuvre of Aggrenox(R)/Asasantin(R)Retard as a primary-line treatment for
secondary stroke prevention is recommended in many international guidelines
such as those issued by the European Stroke Initiative (EUSI), the National
Institute of Health and Clinical Pre-eminence (NICE), the American College of
Chest Physicians (ACCP) as well as the recently issued joint guidelines of
the American Stomach and Flourish Association (AHA/ASA).

Treatments used to lose weight the jeopardy of recurrent tittle available by
inhibiting platelet aggregation and thrombus formation. Aggrenox(R) may
possess multiple mechanisms of actions and additional pharmacological
properties that may bestow on protective antithrombotic activity at the vessel
wall with additional benefits for reducing the chance of frequent
stroke[3],[4],[5].

In the air PRoFESS

The PRoFESS enquiry is a multi-center, randomized, double blind trial
involving 720 sites from 35 countries. Patients 50 years or older who have
had an ischemic stroke within the last 120 days and who were neurologically
and clinically stable, were randomized to the study. The outstanding outcome
for the attempt is the time after time to any cyclical stroke. Secondary outcomes
classify, entirety others, the composite of stroke, myocardial infarction or
vascular decease with or without congestive fundamentals failure, modish onset
diabetes, other designated vascular events. The commensurability between ASA plus
dipyridamole and clopidogrel is everyone to appraise non-inferiority followed by
renown. Blocking the renin angiotensin routine with ACE inhibitors or
ARBs indicates that they reduce stroke. PRoFESS desire discover if
telmisartan shows leadership over placebo in reducing the risk of another
strokes. PRoFESS is a exploration sponsored by Boehringer Ingelheim. For further
information on PRoFESS, please drop in on http://www.hold.com.

About Aggrenox(R)

Aggrenox(R) is an antithrombotic that combines extended freedom
dipyridamole and ASA. A product of Boehringer Ingelheim’s research and
development, it is indicated for the prevention of periodic tittle and
TIA. Marketed as Aggrenox(R) and as Asasantin(R) Retard it is available in
more than 30 countries.

About Action

Stroke is an acute issue, which arises from infirmity of the blood
vessels that supply blood to the brains. A iota or cerebrovascular
chance (CVA) causes sudden impairment to the brain fabric and occurs when a
blood vessel that is carrying oxygen and other nutrients to the brain
bursts or is clogged by a blood clot or particulate papers.[6] The nerve
cells are in want of oxygen and die within minutes. Therefore, bodily
functions under the control of those nerve cells will abort. The effects of
a occurrence are again permanent because the commonplace wisdom cells cannot be
replaced.

About Transient Ischemic Denounce (TIA)

TIA is often called a ‘mini stroke’ with symptoms very similar to a
full stroke including sudden weakness, numbness, clumsiness or pins and
needles on one side of the body; precipitate collapse of, or blurred sight in one or
both eyes; and slurred speech or difficulty finding words. Without
treatment a lodge of people suffering a TIA transfer go on to have a
greatest-blown stroke within a only one years.[7]

About Boehringer Ingelheim

The Boehringer Ingelheim group is bromide of the world’s 20 unsurpassed
pharmaceutical companies. Headquartered in Ingelheim, Germany, it operates
globally with 143 affiliates in 47 countries and almost 37,500 employees.
Since it was founded in 1885, the family-owned company has been committed
to researching, developing, manufacturing and marketing different products of
high therapeutic value quest of human and veterinary medicine.

In 2005, Boehringer Ingelheim posted net sales of 9.5 billion euro
while spending almost a woman fifth of net sales in its largest matter
segment Prescription Medicines on inquire into and development. In requital for more
bumf want visit http://www.boehringer-ingelheim.com

Disclaimer: Press release by reason of ecumenical use. As to the registration
pre-eminence in individual countries, cheer receipt with the friend address
indicated below or liaise with the country-distinct Boehringer Ingelheim
affiliate.

References

[x] Acetylsalicylic acid (ASA) is also marketed as Aspirin(R)

[xx] Nonfatal stroke, death from all vascular causes, nonfatal
myocardial infarction, or major bleeding complication. The dose wander of
ASA in ESPRIT was between 30 and 325mg/day, on mean < 75mg/day. 83% of
the patients received ER DIP, 8% the fixed dose combination ER DROP + ASA
200/25mg twice daily.

[1] Diener HC. Baulk Regimen for Effectively Avoiding Damaged
Strokes (PRoFESS), Baseline Results. Presented on 26 Oct 2006 at Joint
World Congress on Rap

[2] Algra A et al. ESPRIT Scrutiny Conglomeration. Lancet 2006;367(9523):1665-73

[3] Diener HC, Cuhna L, Forbes C, Sivenius J, Smets P, Lowenthal A.
European Rub Warding Study 2 (ESPS-2). Dipyridamole and
acetylsalicylic acid in the backup prevention of caress. J Neurol Sci.
1996 Nov;143(1-2):1-13

[4] Weyrich AS et al. Dipyridamole selectively inhibits inflammatory
gene expression in platelet-monocyte aggregates. Circulation 2005;111(5),
633-642

[5] Eisert WG. Dipyridamole. In Michelson A, copy editor. Platelets. London:
Academic Press; 2002. P803-815

[6] Heart and Stroke Facts. The American Stroke Guild

[7] Transient Ischaemic Attack Backgrounder. The Strike Camaraderie UK

Boehringer Ingelheim

Boehringer Ingelheim

View cure information on Aggrenox; Micardis.